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Psilocybin versus Escitalopram for Major Depressive Disorder
Head-to-head RCT in 59 patients with moderate-to-severe depression found comparable symptom reduction at 6 weeks, with psilocybin showing faster onset and higher remission rates.
New England Journal of Medicine · 2024 · RCT
Stanford SAINT Protocol: Accelerated TMS for Treatment-Resistant Depression
90% remission rate (HAM-D ≤7) in a 5-day intensive course using fMRI-guided sgACC targeting. Sham-controlled RCT with n=29.
American Journal of Psychiatry · 2023 · RCT
Multi-Strain Probiotic Supplementation Modulates Mood via Vagal Afferents
12-week RCT in 124 adults with subthreshold depression showed PHQ-9 reduction of 3.8 points and altered vagal tone on HRV.
Gastroenterology · 2024 · RCT
Machine Learning Prediction of Treatment Response in Bipolar Disorder
Multimodal model (EHR + actigraphy + speech) achieved AUC 0.83 for predicting lithium response across 2,147 patients.
Lancet Psychiatry · 2024 · Prospective
GLP-1 Receptor Agonists and Cognitive Outcomes in Type 2 Diabetes
Retrospective cohort (n=41,608) found semaglutide users had 24% lower incidence of dementia vs matched controls over 4 years.
The Lancet · 2024 · Cohort
Single-Cell Atlas of the Human Prefrontal Cortex Across Major Depressive Disorder
snRNA-seq of 78 donor brains reveals transcriptional signatures in deep-layer pyramidal neurons linked to suicide completion.
Cell · 2024 · Atlas
Clinicians are drowning in research they can't keep up with
medical papers published daily
years average delay for breakthroughs to reach patients
American lives lost annually to outdated practices
“A patient suffered for 10 years with treatment-resistant depression. The Stanford SAINT protocol achieved 90% remission in 5 days — but her doctor never knew it existed.”
Your Personalized Evidence Feed
- Thousands of papers filtered to what matters to you
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Stanford's 5-Day Brain Stimulation Protocol Achieves 90% Remission
Am J Psychiatry · 2020
A revolutionary 5-day protocol using fMRI-guided TMS achieved 90.5% remission in treatment-resistant depression patients.
GLP-1 Receptor Agonists Reduce Major Adverse Cardiac Events by 14%
NEJM · 2025
Large-scale trial demonstrates semaglutide significantly reduces MACE in patients with established cardiovascular disease.
CAR-T Therapy Shows Durable Remission in Relapsed Lymphoma
Lancet Oncol · 2025
5-year follow-up confirms sustained complete response in 40% of patients with relapsed/refractory large B-cell lymphoma.
Early Peanut Introduction Reduces Allergy Risk by 77%
NEJM · 2024
LEAP follow-up study confirms lasting protection from peanut allergy with early introduction in high-risk infants.
Lecanemab Slows Cognitive Decline by 27% in Early Alzheimer's
NEJM · 2025
Phase 3 confirms anti-amyloid antibody moderately slows progression in early-stage Alzheimer's disease over 18 months.
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SciSpark AI
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